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Subsequent multi-species studies found: Delta and spindle EEG enhancement averaging 35% in neocortex and limbic cortex (rabbit models) Slow-wave sleep (SWS) promotion demonstrated in rabbits, rats, mice, and dogs In cats, REM sleep enhancement was more pronounced than SWS promotion A U-shaped dose-response curve was characterized, with optimal effects at specific dose windows Importantly, the sleep-promoting evidence for DSIP itself (as opposed to its structural analogues) is inconsistent

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